While Dipper and Mabel search through a stack of board games in one of the Mystery Shack's closets, they come across the game and think that they could play it before Ford calls for them. The game is never seen again after that.
The board game's box is brown, and the main picture depicts two kids in the middle of a jungle, with the one on the left fleeing from a rhinoceros while the other screams at a snake. The snake is shaped to form the question mark in the title. The subtitle reads, "The last players who opened this box never made it out ALIVE!"
- 215. "The Last Mabelcorn"
- What Could Go Wrong? is a reference to the 1995 film, Jumanji, where two pairs of children play a board game come to life, and in one instance a child is sucked into the board game.